Xlorotiyazid
Fon
Xlorotiyazid karbonat angidrazaning inhibitori bo'lib, atsetazolamiddan bir oz kamroq kuchga ega.Ushbu birikma natriy va xlorid ionlarining reabsorbtsiyasini blokirovka qilishi ko'rsatilgan.
Tavsif
Xlorotiyazid diuretik va antihipertenzivdir.(IC50=3,8 mM) Maqsad: Boshqalar Xlorotiyazid natriy (Diuril) diuretik bo'lib, kasalxonada yoki yurak etishmovchiligi bilan bog'liq ortiqcha suyuqlikni davolash uchun shaxsiy foydalanish uchun ishlatiladi.Bundan tashqari, antihipertenziv sifatida ishlatiladi.Ko'pincha tabletka shaklida olinadi, odatda kuniga bir yoki ikki marta og'iz orqali olinadi.ICU sharoitida bemorga furosemid (Lasix) ga qo'shimcha ravishda diurez qilish uchun xlorotiyazid beriladi.Furosemidga qaraganda alohida mexanizmda ishlaydi va nazogastral naycha (NG trubkasi) orqali yuborilgan qayta tiklangan suspenziya sifatida ichak orqali so'riladi, bu ikki dori bir-birini kuchaytiradi.
Klinik sinov
NCT raqami | Homiy | Vaziyat | Boshlanish vaqti | Bosqich |
NCT03574857 | Virjiniya universiteti | Yurak etishmovchiligi|Ejeksiyon fraktsiyasining kamayishi bilan yurak etishmovchiligi|O'tkir yurak etishmovchiligi|Yurak-qon tomir kasalliklari | 2018 yil iyun | 4-bosqich |
NCT02546583 | Yel universiteti | Milliy yurak, o'pka va qon instituti (NHLBI) | Yurak etishmovchiligi | 2015 yil avgust | Taalluqli emas |
NCT02606253 | Vanderbilt universiteti | Vanderbilt universiteti tibbiyot markazi | Yurak etishmovchiligi | 2016 yil fevral | 4-bosqich |
NCT00004360 | Milliy tadqiqot resurslari markazi (NCRR)|Shimoliy-g'arbiy universitet|Nodir kasalliklar idorasi (ORD) | Diabet insipidus, nefrogenik | 1995 yil sentyabr |
|
NCT00000484 | Milliy yurak, o'pka va qon instituti (NHLBI) | Yurak-qon tomir kasalliklari|yurak kasalliklari|gipertoniya|qon tomir kasalliklari | 1966 yil aprel | 3-bosqich |
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