Rimegepant
Rimegepant - bu kichik molekula inhibitorikalsitoninO'chokli bosh og'rig'ida rol o'ynaydigan kuchli vazodilatator bo'lgan CGRP ta'sirini bloklaydigan gen bilan bog'liq peptid (CGRP) retseptorlari.Rimegepant o'tkir migren hujumlarini davolash uchun tasdiqlangan.Klinik tadkikotlarda rimegepant odatda yaxshi muhosaba qilingan, terapiya davomida sarum aminotransferazasining vaqtincha ko‘tarilishining kamdan-kam holatlari va klinik ko‘rinishda jigar shikastlanishi qayd etilmagan.
Rimegepant - Biohaven Pharmaceuticals tomonidan ishlab chiqilgan CGRP retseptorlarining og'zaki antagonisti.U 2020-yil 27-fevralda migren bosh og'rig'ini o'tkir davolash uchun FDA ruxsatini oldi.CGRP va uning retseptorlarining bir nechta parenteral antagonistlari migrenni davolash uchun tasdiqlangan bo'lsa-da (masalan, [erenumab], [fremanezumab], [galkanezumab]), rimegepant va [ibratli] "gepants" dorilar oilasining ishlab chiqilayotgan yagona a'zolari va og'iz orqali bioavailabilityga ega bo'lgan yagona CGRP antagonistlari.O'chokli terapiyaning hozirgi standarti "triptanlar" bilan abortiv davolashni o'z ichiga oladi, masalan [sumatriptan], ammo bu dori-darmonlar vazokonstriktiv xususiyatlari tufayli miya qon tomirlari va yurak-qon tomir kasalliklari oldindan mavjud bo'lgan bemorlarda kontrendikedir.CGRP yo'lining antagonizmi migren terapiyasi uchun jozibali nishonga aylandi, chunki triptanlardan farqli o'laroq, og'iz orqali yuboriladigan CGRP antagonistlari kuzatilgan vazokonstriktiv xususiyatlarga ega emas va shuning uchun standart terapiyaga qarshi ko'rsatmalari bo'lgan bemorlarda foydalanish uchun xavfsizroqdir.
Rimegepant - aKalsitoninGen bilan bog'liq peptid retseptorlari antagonisti.Rimegepantning ta'sir qilish mexanizmi quyidagichaKalsitoninGen bilan bog'liq peptid retseptorlari antagonisti.
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Taklif18Sifat muvofiqligini baholash loyihalari tasdiqlangan4, va6loyihalari tasdiqlanmoqda.
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Ilg'or xalqaro sifat menejmenti tizimi sotish uchun mustahkam poydevor yaratdi.
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Sifat nazorati sifat va terapevtik ta'sirni ta'minlash uchun mahsulotning butun hayotiy tsiklidan o'tadi.
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Professional tartibga solish bo'yicha guruh ariza va ro'yxatga olish paytida sifat talablarini qo'llab-quvvatlaydi.
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